Does multiple sclerosis (MS) lead to depression?

Multiple sclerosis (MS) researchers have found an increase in the statistics for major depression among people with MS - 50 to 60 percent will suffer depression at some point in their lifetime, as opposed to about 17 percent of those without the disease. University of Toronto researchers have recently found structural changes in the brain, using magnetic resonance imaging, and compared the brains of 21 people with MS and depression to 19 people with MS and no depression. Those with depression did show more signs of lesions and atrophy, but not in every case.

It is now generally accepted that in some patients depression can be caused by MS, not just be a reaction to it. While researchers continue to investigate, it's important to remember that there are many effective new treatments for depression, and a mental health expert should be added to the management team as needed.

Multiple sclerosis (MS) does not by itself mean eventual unemployment. Unfortunately the discrimination and lack of understanding associated with MS can mean just that. Where there are more sophisticated attitudes toward persons with disabilities, more people with MS remain employed.

A 1982 study in Israel showed almost 60 percent of people with MS still employed. In England, where a group of postal employees with disabilities were offered alternative positions, a higher percentage of people remained employed than the average for the rest of the country. Psychological factors can also account for loss of employment.

Depression, lack of motivation, and difficulty in coping are acknowledged factors in unemployment. Finally, there are those who accept early retirement and company pensions on diagnosis without any consideration of their own MS prognosis and type of disability. So, while many people with MS find themselves jobless, it's not necessarily the result of any physical aspect of the disease.

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