What is estrogen-positive and progesterone-positive breast cancer?

Breast cancer cells have proteins on the surface called receptors. When breast cancer tissue is removed during a biopsy or surgery, the tissue is tested in the laboratory. The test looks for certain receptors.

The standard two are estrogen and progesterone. Breast cancer that tests "positive" for these two female hormone receptors probably developed under the influence of these hormones. Cancer that is estrogen and progesterone receptor positive has an important treatment advantage over breast cancer that is negative for these receptors.

Receptor positive cancers usually respond well to drugs that block the action of estrogen or progesterone on the cancer cell. (This is in addition to chemotherapy and/or radiation.) For some women who are hormone receptor positive, treatment with a hormone blocker after surgery might be all the treatment they need. On the other hand, hormone receptor blockers will not be effective for women with hormone receptor negative breast cancer cells.

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