What medications are used to treat irritable bowel syndrome (IBS)?

Medications used to treat irritable bowel syndrome (IBS) include: Serotonin (5HT) receptor agents 5HT3 antagonist alosetron (Lotronex): For global IBS symptoms in women with diarrhea. Significant side effect is constipation. Antidepressants Tricyclic: Used for abdominal pain; possible side effect is constipation.

Selective serotonin reuptake inhinbitor (SSRI): Used for abdominal pain; better tolerated than tricyclics. Gastrointestinal agents Loperamide (Imodium): Used to treat diarrhea; possible side effect is constipation. Fiber/bulking agents: Used for constipation; possible side effect is bloating.

Oral cromolyn sodium: Used for diarrhea; possible side effect is constipation. Selective chloride channel-2 activator lubiprostone (Amitiza): Used for constipation; possible side effects include nausea, diarrhea, and headache.

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