Which antidepressant drugs may help treat irritable bowel (IBS) symptoms?

Antidepressant drugs may be of benefit in the treatment of abdominal pain and discomfort associated with irritable bowel syndrome (IBS); however, the tricyclic antidepressants (TCAs) have proven to be more effective than the selective serotonin reuptake inhibitors (SSRIs) in the small number of scientific studies that have been conducted. The efficacy of SSRIs in treatment of functional gut syndromes such as IBS is currently being investigated.

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