Why do some people get hyper after taking Benadryl while others get sleepy?

The side effects of Benadryl can be sleepiness or excitability. My personal thoughts are that everyone reacts to medicines differently, and we as a family take precautions whenever we are taking a new medicine, whether it be over the counter or prescribed. When we start a new medicine we avoid driving and take it at home, when we know we will be here for a long period of time, just to be sure we are ok if we do experience side effects.

Benadryl like other medicines can be effected if you are taking any other medicines, prescribed or over the counter. You should always talk with your doctor to make sure there will not be any interactions. So I have to wonder if the extreme difference in side effects with Benadryl may be caused by people taking other medicines, on top of Benadryl.

There may be several reasons for some people getting hyper and some people getting sleepy. Maybe it is a combination of many factors. I know you are not able to consume alcohol while taking Benadryl, as well.

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Benadryl effects each person differently. However, it is said to cause hyperactivity in children up to 70% of the time. Because medications effect children differently than it may effect adults, studies have shown that it is not a solution to induce sleep or drowsiness in children.

The effect of hyperactivity from Benadryl is due to the interaction that it has with some users nervous system.

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