I'm reading Ender in Exile right now. YES, it most definitely will spoil the Shadow Series for you. Do NOT read Ender in Exile until you've read up through Shadow of the Giant.
You can, if you want, read Ender in Exile before reading any of the three other sequels to Ender's Game (Speaker for the Dead, Xenocide, Children of the Mind), as Ender in Exile happens before any of them. Ender in Exile starts out immediately after Ender's Game / Ender's Shadow, but all of the Shadow series takes place within the first few chapters of Ender in Exile, and the events that happen at the conclusion of the Shadow series are referred to throught Ender in Exile.
I won't copy and paste the opinion I found. I put the source below. Hope that helps!
So I bought Ender's game and the rest of the series about Ender (Speaker, Xeno, Children) as well as the Bean series (Ender's Shadow, Shadow Hegemon, Shadow Puppets, Shadow of the Giant). In what order should I read them? Obviously I should start with Ender's game but then what next?
Finish the rest of the Ender series and then read the Bean series? , go straight through the Bean series and then finish the Ender series? , or mix the two series?
Is there any chronological overlap between the two series?
I cant really gove you an answer,but what I can give you is a way to a solution, that is you have to find the anglde that you relate to or peaks your interest. A good paper is one that people get drawn into because it reaches them ln some way.As for me WW11 to me, I think of the holocaust and the effect it had on the survivors, their families and those who stood by and did nothing until it was too late.