Do antioxidants interfere with the ability of monocytes and macrophages to utilize respiratory bursting to kill bacteria?

Do antioxidants interfere with the ability of monocytes and macrophages to utilize respiratory bursting to kill bacteria Asked by Mothax 48 months ago Similar questions: antioxidants interfere ability monocytes macrophages utilize respiratory bursting kill bacteria Health.

Similar questions: antioxidants interfere ability monocytes macrophages utilize respiratory bursting kill bacteria.

No they do not intefere with the ability of the monocytes and the macrophages In order to understand what exactly happens you need to understand what happens in the macrophages and monocytes when they phagocyte (eat the bacteria). When one of the phagocytes (macrophages or monocytes) meets with a bacteria and recognizes it (could be through direct recognition or through an antibody that attaches to the bacteria). The the first step is adhesion to the bacteria then the membrane engulfs the bacteria till it becomes a vesicle inside the phagocyte in a process called phagocytosis.

The next stage is that the bactericide material is entering the vesicle which is between other H2O2, which antioxidants work against. Now since this is done in a closed area (in the phagocyte) the antioxidants can not get through it and disable the oxidants in the vesicle, and thus not interfere in the process. Antioxidants work on free radicals that may escape from this process or other processes and may cause damage to the cells (and later cancer), because they are very active and will connect to most molecules in the body.So we want to eliminate this problem and it is done by the antioxidants.

I am also send a few links for some further information on the subject:1. en.wikipedia.org/wiki/Phagocyte2.http://... Luck, Sources: My opinion .

I believe antioxidants dampen the toxic effect of free radicals, but they are in fact required for oxidative burst. This is a very good question! Here is my take on it.... We always hear about how important the consumption of antioxidants is because they hinder highly reactive free radicals - like superoxide anions - from attacking the double bonds of crucial cellular molecules (like DNA).

And there exists a natural accumulation of such dangerous free radicals in cells; this is largely a consequence of energy production in the cell because oxygen serves as the final electron acceptor in the process and thus can readily transform into a free radical. But ATP production and respiratory bursting, which both necessitate the formation of toxic free radicals, must be counter-acted in activated macrophages, so a sufficient supply of antioxidants (and their enzymes) must exist be supplied to the cell. Studies, like the one in the link provided, have shown that macrophage uptake of glutathione (a well known antioxidant) is actually "triggered by the release of H2O2 during the respiratory burst", ensuring the phagocyte is protected against oxidative damage.

This means antioxidants are mandated in the repiratory burst process. And I know what you’re thinking...all this seems counterintuitive. A process like oxidative burst, which promotes the formation and accumulation of free radicals, actually requires the presence of molecules that eliminate free radicals?Yes.

This is because antioxidants "clean up" excess free radicals once they are produced so the cell itself (and surrounding cells) will not be compromised. But antioxidants don’t inhibit the bursting process. These free radicals are localized at the cell's surface and the cellular concentration of antioxidants in this locality of the cell is determined through a transport system contingent on free radical levels.

I suppose you could think of it as a checks and balances system; when too many toxic, reactive species are produced, then the cell allows further uptake of antioxidants to protect itself. Bottom line, not only will antioxidants not interfere with oxidative burst due to complex cellular transport systems, but these molecules are needed to ensure this offensive strategy against microbes does not backfire on the cell itself. I hope this helped out... Sources: jimmunol.org/cgi/content/full/165/6/3333 .

Nope. Macrophages digest foreign particles using a combination of digestive enzymes and strong oxidants (hydroxyl radical, for example). You might think that antioxidants would interfer with the latter effect, but this is really unlikely.

Antioxidants from the diet come as both water soluble types (like vitamin C) and fat soluble types (like tocopherols). Only the fat-soluble ones have much chance of getting into the cell, interfering with intracellular activity. It would take quite massive amounts of such molecules (the fat-soluble ones) to stop macrophages, and you would end up with high toxicity and probably die just from overdosing on those antioxidants long before you would have to worry about your macrophages.As an aside, your question DOES bring up a good point, namely that your body uses both oxidants and antioxidants to stay healthy.

The so-called "peroxide tone" of the cell is an important balance that your body maintains. If you took all the oxidants out, you would certainly die. There is a rare genetic condition, called chronic granulomatous disease, where macrophages lose some of their ability to produce oxidants.

That is quite deadly, giving most CGD sufferers a very short life.

In short, most likely not. And, if they did, it most likely would not matter. Short answer.

The reactive oxidative species that are released are pretty nasty stuff, hydrogen peroxide, reactive oxygen, and an analog of bleech to name a few. I doubt anything in your food or drink would neutralize those. And coming from two doctors, they don’t think that the products of the monocytes and macrophages would be able to get to where you would need them(inside those immune cells).

If antioxidants did have that effect you would see people who take them getting sick more often, which no one seems to have been able to see. Sources: Jonathan .

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Once again--in layman's terms. This user has been banned from Askville.

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Once again--in layman's terms.

I cant really gove you an answer,but what I can give you is a way to a solution, that is you have to find the anglde that you relate to or peaks your interest. A good paper is one that people get drawn into because it reaches them ln some way.As for me WW11 to me, I think of the holocaust and the effect it had on the survivors, their families and those who stood by and did nothing until it was too late.