Down's Syndrome is caused by an abnormality with chromosome #21 Please read the Related Link / Related Question.
Basically, what this section really needs is come out less convoluted and to follow the formatting and direction of the previous ones better; it has all the pieces, but just clashes. The sludge is another clash, but if the section as a whole fits the tone better, the sludge mention would probably have a more ironic effect. United Kingdom - Numbers?
I cant really gove you an answer,but what I can give you is a way to a solution, that is you have to find the anglde that you relate to or peaks your interest. A good paper is one that people get drawn into because it reaches them ln some way.As for me WW11 to me, I think of the holocaust and the effect it had on the survivors, their families and those who stood by and did nothing until it was too late.