In the late 1700's there were major outbreaks of small pox in both Europe and the US. There have also been other epidemics of this disease reported in the early and mid 1800's. You can find more information here: historylink.org/index.cfm?DisplayPage=ou....
I cant really gove you an answer,but what I can give you is a way to a solution, that is you have to find the anglde that you relate to or peaks your interest. A good paper is one that people get drawn into because it reaches them ln some way.As for me WW11 to me, I think of the holocaust and the effect it had on the survivors, their families and those who stood by and did nothing until it was too late.