Amphetamine can be accurately tested up to 72, and variations in time length are due to fluid consumption, intestinal acidity which will influence absorption. From what I've read, niacin is not reliable as an aid to pass a drug test, particularly amphetamine. The sure bet is to abstain for a period of 72+ hours and drink lots of fluids.
If you get used to the regular intake of amphetamines it’s very likely that you will crave to have the drug as frequently as you can. If you consume a high level of the drug, then your system is likely to produce a greater amount of neurotransmitter dopamine. The more the secretion happens in your system, the higher the brain cells are stimulated.
This in turn makes the drug addict feel high which in turn gives seems to give tremendous pleasure for a few hours since consumption. If you get habituated to the intake of high levels of amphetamines, then this might result in serious damage to your brain cells in the long run. At a point of time, when the level of dopamine increases to a remarkable extent, you are likely to undergo the initial symptoms of Parkinson’s disease, a severe movement disorder within your body.
It’s very critical that you stop consuming the drug at this stage.
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