Since centenarians are so rare, is GWA the right technique for studying them?

P.S.: I think one has to be careful about how we interpret the sample sizes. The power is not determined only by the sample size but also by the method you use. T.P.: I think there's another couple of features that made the centenarians a particularly potent sample to perform this study with.

We had evidence for quite some time that this longevity ran very strongly in families. … One of the problems with GWA studies … is that the phenotype can be very different among different people in the study. Here, we have these very old individuals that are more homogenous.

Our primary purpose in conducting this work was to understand the genetic basis of exceptional longevity. … It has nothing to do with trying to get a bunch of people to be 100 or older. More.

I cant really gove you an answer,but what I can give you is a way to a solution, that is you have to find the anglde that you relate to or peaks your interest. A good paper is one that people get drawn into because it reaches them ln some way.As for me WW11 to me, I think of the holocaust and the effect it had on the survivors, their families and those who stood by and did nothing until it was too late.