What happens when LDL cholesterol levels go too low?

Some people can get too low a low-density lipoprotein (LDL) cholesterol level. If your LDL cholesterol goes below 80, I worry that you are at risk of nervous system and immune system dysfunction. And, it can go that low if you are both taking drugs and watching your diet.

The balance of what you should do to make your RealAge (physiologic age) younger is clear: if you have symptoms of severe arterial aging such as angina or inability to walk more than a block or two without having to stop due to calf pain (called intermittent claudication) -- you need to get rid of the plaque by reducing your LDL and raising your HDL cholesterol and not worry about the potential risk of nervous system and immune system dysfunction. But if you do not have symptoms or signs of arterial aging, I do not believe the potential benefits of delaying arterial aging by trying to obtain a LDL level below 80 mg/dL is worth the potential risk of nervous system and immune system dysfunction.

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